In addition to Presteigne St Andrews’ home game against Caersws Reserves there are four other matches in the Spar Mid Wales League.
Third-placed Bow Street will try to maintain the pressure on the leading pair of Penparcau and Rhayader Town when they will host Aberystwyth University – a win for Bow Street would take them to within three points of the leaders with games in hand.
Llanrhaeadr are in sixth place in the table although they are too far off the pace to be directly involved in the title race – they head to Dyffryn Banw.
Tywyn Bryncrug were 2-1 winners at Aberystwyth University on Monday 26 April and they will be back into action on Wednesday night when they again be on the road for a game against Newtown Reserves at Latham Park.
Meanwhile, bottom side Llanfyllin Town will host Waterloo Rovers.
In the Mid Wales League (South), there were two match on Tuesday 27 April in which Builth Wednesdays beat struggling Llandrindod Wells Colts 7-0, while Talgarth Town also netted seven times – they came away from Radnor Valley with a 7-2 victory.
The Wednesday night action at this level will see Llandrindod Wells start as clear favourites in their home game against Sennybridge, while Talgarth Rovers head to Rhayader Town Reserves.